Osmotic device containing amantadine and an osmotic salt

Details Osmotic device containing amantadine and an osmotic salt Osmotic device containing amantadine and an osmotic salt

A - Human Necessities

61

K

A61K 31/13 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2589479

The invention relates to osmotic devices containing a unitary core which comprises an amantadine salt and an osmotic salt, in which the two salts have a common ion. The amantadine release speed is modified from a first order release profile to a zero order, pseudo zero order or sigmoidal release profile by increasing the quantity of osmotic salt in the core of the device. The osmotic device includes a semi-permeable membrane with a controlled porosity which can be adapted as required in order to co-operate with the osmotic salt in providing a pre-determined drug-release profile. The osmotic salt does not have to be covered and is mixed with the amantadine salt.

Dispositifs osmotiques contenant un noyau unitaire qui comprend un sel d'amantadine et un sel osmotique, les deux sels possédant un ion en commun. La vitesse de libération d'amantadine est modifiée passant d'un profil de libération de premier ordre à un profil de libération d'ordre nul, d'ordre pseudo-nul ou sigmoïde, lorsque la quantité de sel osmotique dans le noyau du dispositif augmente. Le dispositif osmotique comprend une membrane semi-perméable qui présente une porosité contrôlée susceptible d'être adaptée au besoin, afin de coopérer avec le sel osmotique pour conférer à un médicament un profil de libération prédéterminé. Le sel osmotique ne nécessite pas d'être recouvert et est mélangé avec le sel d'amantadine.

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