A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/44 (2006.01)
Patent
CA 2683068
The present invention refers to a tablet-shaped osmotic release system providing, in a controlled way, active principles which solubility depends on the pH of the medium, simultaneously providing appropriate solubilization throughout the gastrointestinal tract. The pharmaceutical osmotic release system comprises of a pharmaceutical layer, which contains at least one active principle in a solid solution, a propelling layer, which contains at least one osmopolymer and at least one osmoagent, a semipermeable coating involving both layers, and at least one orifice in the semipermeable coating at the side of the pharmaceutical layer.
La présente invention concerne un système à libération osmotique sous forme de comprimé fournissant, de façon contrôlée, des principes actifs dont la solubilité dépend du pH du milieu, et simultanément une solubilisation appropriée dans tout le tractus gastro-intestinal. Le système à libération osmotique pharmaceutique est constitué d'une couche pharmaceutique, qui contient au moins un principe actif dans une solution solide, d'une couche de propulsion, qui contient au moins un osmopolymère et au moins un osmoagent, d'un revêtement semi-perméable impliquant les deux couches, et d'au moins un orifice ménagé dans le revêtement semi-perméable du côté de la couche pharmaceutique.
Gowling Lafleur Henderson Llp
Libbs Farmaceutica Ltda.
LandOfFree
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