Osmotic tablet with a compressed outer coating

Details Osmotic tablet with a compressed outer coating Osmotic tablet with a compressed outer coating

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2741701

The present invention features a method of manufacturing an osmotic tablet including the steps of (i) compressing a tablet core including a first pharmaceutically active agent and a hydrophilic polymer; (ii) applying an osmotic coating to the outer surface of the tablet core to form a coated tablet, wherein the osmotic coating includes at least one opening exposing the tablet core; and (iii) compressing an immediate release coating onto the surface of the coated tablet, wherein the release coating includes a second pharmaceutically active agent.

La présente invention concerne un procédé de fabrication dun comprimé osmotique qui comprend les étapes consistant à (i) compacter un noyau de comprimé comprenant un premier agent pharmaceutiquement actif et un polymère hydrophile; (ii) appliquer un revêtement osmotique sur la surface extérieure du noyau de comprimé pour former un comprimé enrobé, le revêtement osmotique comprenant au moins une ouverture exposant le noyau de comprimé; et (iii) compacter un revêtement à libération immédiate sur la surface du comprimé enrobé, le revêtement à libération immédiate comprenant un second agent pharmaceutiquement actif.

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