Osteoarthritis cartilage regeneration using human...

A - Human Necessities – 61 – K

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A61K 35/28 (2006.01) C12N 5/0775 (2010.01) A61K 35/32 (2006.01) A61K 38/19 (2006.01) A61L 27/38 (2006.01) A61K 35/12 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2288690

For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: 1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); 2) broaden the suitable clinical population to routinely include middle-aged patients; 3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; 4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; 5) regenerate articular joint cartilage in older patients with osteoarthritis; and 6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

La présente invention permet de réparer le cartilage endommagé à la suite des effets dégénératifs de l'arthrose grâce à un procédé faisant appel à des cellules souches mésenchymateuses humaines, lequel procédé permet: (1) de régénérer le cartilage superficiel atteint d'anomalies cartilagineuses ainsi que le cartilage profond atteint d'anomalies telles que des lésions ostéo-cartilagineuses; (2) d'élargir la population clinique indiquée habituelle afin d'y inclure les patients d'âge moyen; (3) d'éviter l'utilisation de greffes de tissus autologues (cartilage mûr et couche périostique) dans la réparation d'une lésion du cartilage articulaire; (4) de régénérer d'autres types de cartilage atteint tel que le cartilage de la rotule et du disque spinal; (5) de régénérer le cartilage des articulations chez les patients âgés souffrant d'arthrose; et (6) de former un nouveau cartilage et os sous-chondral qui s'intègrent parfaitement dans les tissus normaux adjacents.

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