A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2554825
Human osteogenic cells secrete biological activities that stimulate cancer cells to migrate to and/or invade tissues. Conditioned medium (CM) produced by human pre-osteoblasts and osteoblasts induced migration and tissue invasion of human prostate cancer cells. Thus, conditioned media and/or proteins isolated therefrom may be used to identify metastasis-inducing factors. Also described are methods of identifying an inhibitor of such factors.
Les cellules ostéogéniques humaines sécrètent des activités biologiques stimulant la migration et/ou l'invasion des cellules cancéreuses dans les tissus. Un milieu conditionné (CM) produit par des pré-ostéoblastes et des ostéoblastes humains a induit une migration et une invasion tissulaire des cellules du cancer de la prostate humain. Ainsi, les milieux conditionnés et/ou les protéines isolées de ceux-ci peuvent être utilisés pour identifier les facteurs induisant des métastases. L'invention concerne également des méthodes d'identification d'un inhibiteur de ces facteurs.
Hall Christopher L.
Long Michael W.
Bcf Llp
The Regents Of The University Of Michigan
LandOfFree
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