A - Human Necessities – 61 – F
Patent
A - Human Necessities
61
F
A61F 2/28 (2006.01) A61L 27/04 (2006.01) A61L 27/12 (2006.01) A61L 27/14 (2006.01) A61L 27/24 (2006.01) A61L 27/52 (2006.01)
Patent
CA 2729917
Implants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the engineered tissue for attaching the implant to a native bone of the biological organism. The engineered tissue includes a scaffold containing a biocompatible material, and a plurality of living chondrocytes supported by the scaffold. Methods for culturing chondrocytes for incorporation into a biocompatible implant are provided. A bioreactor for producing functional cartilaginous tissue from a cell-seeded scaffold and a system for producing functional cartilaginous tissue are also provided.
La présente invention concerne des implants utilisables pour le resurfaçage ou la réparation d'une ou plusieurs surfaces recouvertes de cartilage articulaire au sein d'un organisme biologique. Ces implants comprennent un tissu complexe et un substrat poreux biocompatible fixé au tissu complexe en vue de la fixation de l'implant à un os naturel de l'organisme biologique. Ce tissu complexe comporte un squelette contenant un matériau biocompatible et une pluralité de chondrocytes vivants supportés par le squelette. L'invention concerne également des procédés de culture de chondrocytes en vue de leur incorporation dans un implant biocompatible. L'invention concerne encore un bioréacteur permettant la production de tissu cartilagineux fonctionnel à partir d'un squelette ensemencé par des cellules, ainsi qu'un système de production de tissu cartilagineux fonctionnel.
Ateshian Gerard A.
Bian Li Ming
Cook James L.
Hung Clark T.
Lima Eric G.
Smart & Biggar
The Curators Of The University Of Missouri
The Trustees Of Columbia University In The City Of New York
LandOfFree
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