A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/57 (2006.01)
Patent
CA 2621157
The present invention discloses osteogenic and anti-adipogenic oxysterols. Agents and methods for protecting, blocking or rescuing marrow stromal cells from the inhibitory effects of oxidative stress on their osteoblastic cellular differentiation are disclosed. Exemplary agents include oxysterols alone or in synergistic combinations, as well as hedgehog or Wnt signaling activators. The synergistic effects of oxysterols and bone morphogenic proteins are also disclosed.
L'invention concerne des oxystérols ostéogéniques et anti-adipogéniques. Elle concerne également des agents et des procédés destinés à protéger, à bloquer ou à sauver des cellules de stroma de moelle, vis-à-vis des effets inhibiteurs ou d'une contrainte oxydante sur leur différentiation cellulaire ostéoblastique. Des agents mentionnés à titre d'exemple comprennent des oxystérols, seuls ou en combinaisons synergiques, ainsi que des activateurs de signalisation Hedgehog ou Wnt. L'invention concerne également les effets synergiques des oxystérols et des protéines morphogéniques osseuses.
Sim & Mcburney
The Regents Of The University Of California
LandOfFree
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