C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/327, 530/15.
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61L 27/22 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2000498
The present invention provides an osteogenically active protein preparation characterized by a molecular weight of from about 31,000 to 34,000 daltons as characterized by non-reducing sodium dodecyl sulfate polyacrylamide gel electrophoresis and by the characteristic of eluting from a reverse phase high performance liquid chromatography column equilibrated with buffers containing trifluoroacetic acid and acetonitrile by eluting within the concentrations of 35~ to 45% acetonitrile. The invention further provides improved methods for isolating such preparations and genes encoding all or a portion of polypeptide subunits of dimers comprising the osteogenic protein preparation.
Grinna Lynn
Hersh Carol
Parsons Thomas F.
Sen Arup
Theofan Georgia
International Genetic Engineering Inc.
Ridout & Maybee Llp
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