C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61P 17/02 (2006.01) A61P 19/08 (2006.01) C07K 1/22 (2006.01) C07K 1/36 (2006.01) C07K 5/103 (2006.01) C07K 14/51 (2006.01)
Patent
CA 2157506
The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr--Gly-Phe-His-Gly and Gly-Phe-Gly-Gly. The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic of fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.
Bab Itai
Chorev Michael
Greenberg Zvi
Mansur Nura
Muhlrad Andras
Goldin Douglas Michael
Macrae & Co.
Yissum Research Development Company Of The Hebrew University Of
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