Osteogenic oligonucleotides and uses thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/711 (2006.01) A61K 31/7125 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2581665

Oligonucleotides having the ability to stimulate osteogenesis in vertebrate animals, including humans, are disclosed. These osteogenic oligonucleotides can be used in a wide range of clinical procedures to replace and restore osseous and periodontal defects or to facilitate the successful implantation of prosthesis and distraction procedures in bones. Methods for generation of bone in an area of an animal where skeletal tissue is deficient are provided. They consist in the local or systematic administration of a composition comprising one or more of the osteogenic oligonucleotides to the animal, in a pharmaceutically acceptable carrier. The composition is administered in an amount effective to induce osteogenesis at the bone site.

L'invention concerne des oligonucléotides qui peuvent stimuler l'ostéogenèse chez des animaux vertébrés, notamment chez l'homme. Ces oligonucléotides ostéogéniques peuvent être utilisés dans une large gamme d'interventions cliniques pour remplacer et restaurer des défauts osseux et parodontaux ou pour faciliter une implantation réussie de prothèse et des interventions de distractions osseuses. L'invention concerne également des procédés de génération d'os dans une région d'un animal dans laquelle les tissus squelettiques sont déficients. Ces procédés consistent à administrer de manière locale ou systématique une composition comprenant un ou plusieurs desdits oligonucléotides ostéogéniques à l'animal, dans un excipient acceptable sur le plan pharmaceutique. La composition est administrée à une dose efficace afin d'induire une ostéogenèse sur le site de l'os.

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