Osteopenia animal model

A - Human Necessities – 01 – K

Patent

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Details

A01K 67/027 (2006.01) A01K 67/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2666443

Disclosed are: a method for producing an osteopenia model animal by administering RANKL; and an osteopenia model animal. Specifically disclosed are: a method for producing an osteopenia model animal, which comprises administering soluble RANKL or a fusion protein of soluble RANKL and an epitope tag to a non-human animal to stimulate the differentiation and activation of an osteoclast in the non-human animal; and an osteopenia model animal produced by the method.

L'invention porte sur un procédé de production d'un animal modèle d'ostéopénie par l'administration de RANKL, et sur un animal modèle d'ostéopénie. L'invention porte spécifiquement sur un procédé de production d'un animal modèle d'ostéopénie, lequel procédé comprend l'administration de RANKL soluble ou d'une protéine de fusion de RANKL soluble et d'un marqueur d'épitope à un animal non humain pour stimuler la différenciation et l'activation d'un ostéoclaste dans l'animal non humain. L'invention porte également sur un animal modèle d'ostéopénie obtenu par le procédé.

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