Osteopontin for the prediction and treatment of...

A - Human Necessities – 61 – K

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A61K 35/12 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) A61L 27/22 (2006.01) C07K 14/52 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2679545

Osteopontin for the prediction and treatment of cardiovascular diseases The present invention relates to the use of endothelial progenitor cells (EPCs) and osteopontin for the treatment of cardiovascular diseases or complications. The invention also relates to the use of EPC osteopontin levels as a marker of the risk of the development of these cardiovascular complications. In particular, the invention provides compositions and methods based on osteopontin and the genes encoding osteopontin.

La présente invention concerne l'utilisation de cellules progéniteurs endothéliales (EPC) et d'ostéopontine pour le traitement de maladies ou de complications cardiovasculaires. L'invention concerne également l'utilisation des taux d'ostéopontine des EPC comme un marqueur du risque de développement de ces complications cardiovasculaires. En particulier, l'invention procure des compositions et des procédés basés sur l'ostéopontine et les gènes codant pour l'ostéopontine.

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