Osteoporosis treatment

Details Osteoporosis treatment Osteoporosis treatment

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237915

There is disclosed a process of treating or alleviating the symptoms of pathological conditions involving increased bone resorption, which comprises inhibiting, in a mammalian patient suffering from such a condition, the formation in vivo of a tertiary complex of IL-11, its cell surface membrane receptor and the cell surface glycoprotein gp130. Examples of such substances are recombinant soluble IL-11 receptor mutants modified, as compared with native IL-11 receptor, at its gp130 binding site. The process of the invention not only inhibits bone resorption and hence bone loss, but also reverses the process to cause bone formation.

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