Osteoprotegerin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/19 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 17/08 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210467

The present invention discloses a secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.

L'invention porte sur un polypeptide sécrété, dit ostéoprotégérine, membre de la superfamille des récepteurs du facteur de nécrose tumorale jouant un rôle dans la régulation du métabolisme osseux. Elle porte également sur des acides nucléiques codant l'ostéoprotégérine, sur des polypeptides, sur des vecteurs de recombinaison, sur des cellules hôtes d'expression, sur des anticorps se fixant à l'ostéoprotégérine et sur des préparations pharmaceutiques. Lesdits polypeptides sont utilisés pour le traitement des maladies osseuses caractérisées par une résorption accrue, telles que l'ostéoporose.

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