A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/724 (2006.01) A61K 31/198 (2006.01) A61K 31/41 (2006.01) A61K 31/519 (2006.01) A61P 27/16 (2006.01)
Patent
CA 2472678
In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic and at least one otoprotectant selected from the group consisting of a xanthine oxidase inhibitor and a glutathione or glutathione precursor. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic, at least one xanthine oxidase inhibitor, at least one glutathione or glutathione precursor. In another aspect, the present invention provides methods for ameliorating hearing loss by administering to a subject an amount of an otoprotective composition that is effective to ameliorate hearing loss.
Dans un mode de réalisation, l'invention concerne des compositions de protection auditive utiles concernant l'amélioration de l'état de surdité. Dans d'autres modes de réalisations, les compositions de protection auditive comprennent au moins un mimétique de glutathion peroxydase et au moins un protecteur auditif sélectionné parmi le groupe comprenant un inhibiteur de xanthine oxydase, du glutathion et un précurseur de glutathion. Dans certains modes de réalisation, les compositions de protection auditive comprennent au moins un mimétique de glutathion peroxydase, au moins un inhibiteur de xanthine oxydase, et au moins du glutathion ou un précurseur de glutathion. Dans un dernier mode de réalisation, l'invention concerne des procédés d'amélioration de l'état de surdité par administration à un sujet d'une quantité efficace de composition de protection auditive améliorant son état de surdité.
Kil Jonathan
Lynch Eric D.
Gowling Lafleur Henderson Llp
Sound Pharmaceuticals Incorporated
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