Ouabain-specific monoclonal antibodies

Details Ouabain-specific monoclonal antibodies Ouabain-specific monoclonal antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/44 (2006.01) A61K 39/395 (2006.01) A61P 3/00 (2006.01) A61P 9/12 (2006.01) C12N 5/20 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2386519

The invention relates to a monoclonal antibody or antigen binding fragment thereof having binding specificity for ouabain, wherein the antibody or antigen binding fragment does not crossreact with digoxin. Preferably the anti- ouabain monoclonal antibody can bind ouabain with an affinity of at least about 10-7M, preferably 10-8M, and more preferably 10-9M. The invention also relates to diagnostic and therapeutic uses of the monoclonal antibodies described herein.

L'invention concerne un anticorps monoclonal ou un fragment de celui-ci liant l'antigène, possédant une spécificité de liaison à la ouabaïne. Cet anticorps ou fragment liant l'antigène ne produit pas de réaction croisée avec la digoxine. L'affinité de liaison de cet anticorps monoclonal anti-ouabaïne avec la ouabaïne atteint de préférence au moins 10?-7¿M environ, voire 10?-8¿M, ou mieux encore 10?-9¿M. L'invention concerne également des utilisations diagnostiques et thérapeutiques de ces anticorps monoclonaux.

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