C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01) C07K 16/42 (2006.01) C12N 5/16 (2006.01) G01N 33/574 (2006.01) C12N 5/09 (2010.01)
Patent
CA 2381706
The present invention is directed to cell surface antigenes found on myeloma cells and on ovarian cancer cells that are recognized by monoclonal antibodies, and antibody binding fragments thereof, as described. The monoclonal antibodies of the invention are capable of being used for therapeutic, screening, diagnostic and cell purification purposes. A representative and exemplified monoclonal antibody of the present invention recognizes and binds to an epitope common to a surface antigen that is expressed on multiple myeloma cells and to a surface antigen that is expressed on ovarian cancer cells. The function of this monoclonal antibody both in vivo and in vitro is demonstrated.
L'invention concerne des antigènes de surface cellulaires trouvés à la surface de cellules myélomateuses et de cellules cancéreuses ovariennes, reconnus par des anticorps monoclonaux, et des fragments de liaison d'anticorps de ces anticorps monoclonaux. Les anticorps monoclonaux peuvent s'utiliser à des fins thérapeutiques, et à des fins de criblage, de diagnostic et de purification cellulaire. Un exemple d'anticorps monoclonal représentatif reconnaît un épitope commun à un antigène de surface exprimé sur la surface de multiples cellules myélomateuses et se lie à celui-ci. Il se lie également à un antigène de surface exprimé à la surface de cellules cancéreuses ovariennes. La fonction de cet anticorps monoclonal est démontrée à la fois in vivo et in vitro.
Immunocellular Therapeutics Ltd.
Molecular Discoveries L.l.c.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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