Over-coated chewing gum formulations including tableted center

Details Over-coated chewing gum formulations including tableted center Over-coated chewing gum formulations including tableted center

A - Human Necessities

61

K

A61K 9/68 (2006.01) A23G 4/00 (2006.01) A23G 4/12 (2006.01) A23G 4/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2426349

Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system.

La présente invention concerne des procédés et des produits de distribution d'un médicament ou d'un agent à un individu, ainsi que des procédés de production du produit. Ledit produit comprend un enrobage contenant un médicament ou un agent. Ledit médicament ou ledit agent est présent dans l'enrobage qui entoure un centre de tablette de gomme (la partie hydrosoluble et une partie de base insoluble dans l'eau). Le fait de mastiquer la gomme permet de libérer le médicament ou l'agent du produit. Le fait de continuer à mastiquer la gomme à mâcher créé une pression dans la cavité buccale, poussant l'agent ou le médicament directement dans le système systémique de l'individu par l'intermédiaire de la muqueuse buccale contenue dans ladite cavité. Cela favorise considérablement l'absorption du médicament dans le système systémique ainsi que la biodisponibilité du médicament dans le système.

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