Overcoming dapa aminotransferase bottlenecks in biotin vitamers

Details Overcoming dapa aminotransferase bottlenecks in biotin vitamers Overcoming dapa aminotransferase bottlenecks in biotin vitamers

C - Chemistry, Metallurgy

12

N

C12N 1/21 (2006.01) C07D 495/04 (2006.01) C12P 13/00 (2006.01) C12P 17/10 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2242145

A process is disclosed for the increased production of biotin and the biotin precursor dethiobiotin using a bacterium that produces a lysine-utilizing DAPA aminotransferase. The process involves the use of a bacterium that is either grown in the presence of lysine or deregulated for lysine biosynthesis.

Divulgation d'un processus pour une production accrue de biotine et du précurseur de la biotine, la déthiobiotine, au moyen d'une bactérie produisant une DAPA aminotransférase qui utilise la lysine. Le processus met en jeu l'utilisation d'une bactérie cultivée en présence de lysine ou dont la voie de la biosynthèse de la lysine a été dérégulée.

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