Overexpressing human methenyltetrahydrofolate synthetase to...

Details Overexpressing human methenyltetrahydrofolate synthetase to... Overexpressing human methenyltetrahydrofolate synthetase to...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/505 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2271267

The present invention relates to enhancing the antineoplastic effects of the anticancer drug 5-fluorouracil (5-FU) in human cancer cells by overproducing the human enzyme methenyltetrahydrofolate synthetase (MTHFS). More particularly, the invention uses MTHFS transgene for sensitizing tumor cells to the cytotoxic effects of 5-FU. The MTHFS transgene is delivered into tumor cells by liposomes. The MTHFS transformed tumor cells highly respond to the anti-cancer drug 5-FU.

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