C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2670696
Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal,. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
L'invention concerne des anticorps isolés et des fragments de liaison d'antigènes de ceux-ci dirigés contre Ovr110 exprimé par la tête et le cou, l'ovaire, l'endomètre, le rein, le cancer du pancréas, des poumons ou du sein. L'invention concerne également des cellules et leurs procédés de production ainsi que leurs procédés d'utilisation pour tuer des cellules cancéreuse exprimant Ovr110 et atténuer ou traiter un cancer exprimant Ovr110 chez un mammifère. Les anticorps anti-Ovr110 modulent la fonction d'Ovr110 ou s'internalisent lors de la liaison au Ovr110 exprimé par des cellules de mammifères in vitro et in vivo. L'invention concerne en outre des compositions comprenant un anticorps anti-Ovr110 et un support ainsi que des articles manufacturés et des rousses associées. De plus, elle concerne des acides nucléiques isolés codant un anticorps anti-Ovr110, des vecteurs d'expression contenant ces acides nucléiques, et des cellules hôtes contenant ces vecteurs.
Diedrich Gundo
Liu Shu-Hui
Nowakowski Agnes
Papkoff Jackie
Borden Ladner Gervais Llp
Diadexus Inc.
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