Ovr110 antibody compositions and methods of use

Details Ovr110 antibody compositions and methods of use Ovr110 antibody compositions and methods of use

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2586313

The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110~expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.

L'invention concerne des anticorps dirigés contre des antigènes du cancer de l'ovaire, du pancréas, du poumon ou du sein (Ovr110) qui s'internalisent lors d'une liaison à Ovr110 sur un mammifère in vivo. L'invention concerne également des compositions comprenant un anticorps anti-Ovr110 et un support. Ces compositions peuvent être fournies dans un article de fabrication ou une trousse. Un autre aspect de l'invention concerne un acide nucléique isolé codant pour un anticorps anti-Ovr110 ainsi qu'un vecteur d'expression comprenant cet acide nucléique isolé. L'invention concerne également des cellules produisant ces anticorps anti-Ovr110. Elle se rapporte en outre à une méthode destinée à produire ces anticorps anti-Ovr110. D'autres aspects de l'invention concernent une méthode destinée à provoquer la mort d'une cellule cancéreuse exprimant Ovr110 et consistant à mettre la cellule cancéreuse en contact avec un anticorps anti-Ovr110, ainsi qu'une méthode destinée à atténuer ou traiter un cancer exprimant Ovr110 chez un mammifère et consistant à administrer une dose thérapeutiquement efficace de cet anticorps anti-Ovr110 à ce mammifère.

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