C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) C12P 21/08 (2006.01) G01N 33/48 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2525899
The invention provides isolated anti-ovarian, pancreatic, lung or breast cancer antigen (Ovr110) antibodies that internalize upon binding to Ovr110 on a mammalian in vivo. The invention also encompasses compositions comprising an anti-Ovr110 antibody and a carrier. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Ovr110 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Ovr110 antibodies. The invention encompasses a method of producing the anti-Ovr110 antibodies. Other aspects of the invention are a method of killing an Ovr110-expressing cancer cell, comprising contacting the cancer cell with an anti-Ovr110 antibody and a method of alleviating or treating an Ovr110-~expressing cancer in a mammal, comprising administering a therapeutically effective amount of the anti-Ovr110 antibody to the mammal.
L'invention porte sur des anticorps isolés de l'anti-antigène Ovr110 des cancers de l'ovaire, du pancréas, du poumon ou du sein, qui s'internalisent en se fixant in vivo à l'Ovr110 de mammifères, et sur des compositions comprenant des anticorps anti-Ovr110 et un support, pouvant se présenter comme article manufacturé ou comme trousse. L'invention porte également sur un acide nucléique isolé codant pour un anticorps anti-Ovr110, sur un vecteur d'expression comprenant l'acide nucléique isolé, et sur des cellules produisant des anticorps anti-Ovr110. L'invention porte en outre sur une méthode de destruction de cellules cancéreuses consistant à les mettre en contact avec un anticorps anti-Ovr110, et sur une méthode atténuant ou traitant les cancer de mammifères exprimant des Ovr110, consistant à leur administrer une quantité à effet thérapeutique d'anticorps anti-Ovr110.
Corral Laura
Keller Gilbert-Andre
Li Wenlu
Papkoff Jackie
Pilkington Glenn
Borden Ladner Gervais Llp
Diadexus Inc.
LandOfFree
Ovr110 antibody compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ovr110 antibody compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ovr110 antibody compositions and methods of use will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1781386