Ox40r binding agents

Details Ox40r binding agents Ox40r binding agents

C - Chemistry, Metallurgy

12

N

C12N 15/28 (2006.01) A61K 38/19 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2480694

The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with natural OX40L for blocking OX40R-mediated cell signaling in the prophylaxis and/or treatment of diseases related to activated T cells.

La présente invention concerne des peptides isolés à partir du domaine extracellulaire du ligand OX40 (OX40L) capable de se lier au récepteur OX40 (OX40R) et d'inhiber l'interaction entre OX40R et OX40L. De tels peptides, les protéines de fusion les comprenant, ainsi que des peptides et autres molécules construites sur leurs séquences, conviennent comme agents liants de OX40R entrant en concurrence avec le OX40L naturel pour bloquer la signalisation cellulaire à médiation OX40R pour la prévention et/ou le traitement d'affections en relation avec des lymphocytes T activés.

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