Oxa- and thiadiazoles and their use as metalloproteinase...

Details Oxa- and thiadiazoles and their use as metalloproteinase... Oxa- and thiadiazoles and their use as metalloproteinase...

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 29/00 (2006.01) C07D 285/08 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2475867

Compounds formula (IA) or (IB), wherein W represents HO(C=O)-, HONH(C=O)- or H(C=O)N(OH)-; X represents -O- or -S-; and R~1, R~2, and R~3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.

L'invention concerne des composés de formule (IA) ou (IB), dans lesquelles W représente HO(C=O)-, HONH(C=O)- ou H(C=O)N(OH)-; X représente -O- ou -S-; et R1, R2, et R3 sont tels que définis dans le descriptif et les revendications. Les composés de cette invention sont des inhibiteurs de métalloprotéinases matricielles, plus particulièrement de MMP9 et/ou MMP12.

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