Oxadiazole compounds as urokinase inhibitors

Details Oxadiazole compounds as urokinase inhibitors Oxadiazole compounds as urokinase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 311/13 (2006.01) A61K 31/18 (2006.01) A61K 31/4245 (2006.01) C07D 271/07 (2006.01)

Patent

CA 2620683

The present invention relates to novel compounds which inhibit urokinase- plasminogen activator (uPA), have a high bioavailability and can be administered orally, and to their use as therapeutic active substances for the treatment of disorders associated with urokinase and/or urokinase receptor, for example tumours and metastasis. The invention relates in particular to compounds containing oxadiazole groups.

La présente invention concerne de nouveaux composés conçus pour inhiber l'activateur du plasminogène de type urokinase (uPA). Ces composés présentent une grande biodisponibilité et peuvent être administrés par voie orale. Cette invention concerne également l'utilisation de ces composés en tant que substances actives thérapeutiques pour traiter des maladies qui sont associées à l'urokinase et/ou au récepteur d'urokinase, telles que des maladies avec des tumeurs et des métastases. En outre, cette invention concerne des composés contenant notamment des groupes oxadiazole.

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