Oxadiazole derivatives as s1p1 receptor agonists

Details Oxadiazole derivatives as s1p1 receptor agonists Oxadiazole derivatives as s1p1 receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/435 (2006.01) A61P 37/06 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2748394

New compounds having the chemical structure of formula (I) or pharmaceutically acceptable salts or N-oxides thereof wherein A is selected from the group consisting of -N-, -O- and -S-; B and C independently are selected from the group consisting of -N- and -O-, with the proviso that at least two of A, B and C are nitrogen atoms; G1 is selected from the group con-sisting of nitrogen atoms and -CR c- groups, wherein R c represents a hydrogen atom, a halogen atom, a C1-4 alkyl group or a C1-4 alkoxy group.

La présente invention concerne de nouveaux composés ayant la structure chimique de formule (I) ou des sels pharmaceutiquement acceptables ou des N-oxydes de ceux-ci dans laquelle A est choisi dans le groupe comprenant -N-, -O- et -S-; B et C sont indépendamment choisis dans le groupe comprenant -N- et -O-, à condition qu'au moins deux parmi A, B et C soient des atomes d'azote; G1 est choisi dans le groupe comprenant des atomes d'azote et les groupes -CRc-, où Rc représente un atome d'hydrogène, un atome d'halogène, un groupe alkyle en C1 à C4 ou un groupe alcoxy en C1 à C4;

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