Oxadiazole derivatives for the treatment of diabetes

Details Oxadiazole derivatives for the treatment of diabetes Oxadiazole derivatives for the treatment of diabetes

C - Chemistry, Metallurgy

07

D

C07D 271/113 (2006.01) A61K 31/4245 (2006.01) A61P 3/10 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2734397

The invention relates to novel oxadiazole derivatives of formula (I) wherein R, R', Y, X1, X2 and X3 have the designations cited in claim 1. Said derivatives are kinase inhibitors and can be used to treat illnesses and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonal hypertonia, cardiovascular diseases and kidney diseases, any type of fibrosis, inflammatory processes, tumours, and tumour diseases.

L'invention concerne de nouveaux dérivés d'oxadiazol représentés par la Formule (I), dans laquelle R, R, Y, X1, X2 et X3 ont la signification figurant dans la revendication 1, qui sont des inhibiteurs de kinase et peuvent être utilisés le traitement de maladies et de troubles tels que le diabète, l'obésité, le syndrome métabolique (dyslipidémie), lhypertonie systémique et pulmonaire, les maladies cardiovasculaires et rénales, tous types de fibroses, les processus inflammatoires, les tumeurs et les maladies tumorales.

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