Oxadiazole derivatives having anticancer effects

Details Oxadiazole derivatives having anticancer effects Oxadiazole derivatives having anticancer effects

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2406685

A pharmaceutical composition for the treatment or prevention of cancer, comprising a compound of the general formula (I) as an active ingredient: (see formula I) or a prodrug, a pharmaceutically-acceptable salt, or a solvate thereof, wherein R1 is hydroxyl or the like; R2 is optionally substituted lower alkyl or the like; R3 is hydrogen or the like; R4 is optionally substituted arylene or the like; and R5 is optionally substituted aryl or the like.

Cette invention a trait à des compositions pharmaceutiques aux fins du traitement ou de la prévention d'états pathologiques glomérulaires, contenant comme ingrédient actif des composés correspondant à la formule générale (I), ainsi qu'à leurs promédicaments, à leurs sels admissibles du point de vue pharmaceutique ou à leurs solvates. Dans cette formule, R<1> représente un hydroxy ou analogue, R<2> représente un alkyle de faible poids moléculaire éventuellement substitué ou analogue, R<3> représente un hydrogène, R<4> représente un arylène éventuellement substitué ou analogue et R<5> représente un aryle éventuellement substitué ou analogue.

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