C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/4245 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01) C07D 261/08 (2006.01) C07D 261/14 (2006.01) C07D 271/06 (2006.01) C07D 271/07 (2006.01) C07D 271/10 (2006.01) C07D 271/107 (2006.01) C07D 271/113 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2495120
The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4, R, R1, R2, R3, R4, R5, R6, R7, m, n, o, p and q are defined as in any one of claims 1 to 12, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy. It has been found that the compounds according to the present invention, or salts therof, exhibit a high degree of potency and selectivity for individual metabotropic glutamate receptor (mGluR) subtypes. In particular there are compounds according to the present invention that are potent and selective for the mGluR Group I receptor and more particularly for mGluR5. Thus, it is expected that the compounds of the invention are well suited for the prevention and/or treatment of mGluR5 receptor-mediated disorders such as acute and chronic neurological and psychiatric disorders and chronic and acute pain disorders.
L'invention concerne de nouveaux composés de formule (I), dans laquelle P, Q, X?1¿, X?2¿, X?3¿, X?4¿, R, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, m, n, o, p et q sont définis dans n'importe laquelle des revendications 1 à 12, un procédé pour leur préparation, de nouveaux intermédiaires préparés selon ledit procédé, des formulations pharmaceutiques contenant lesdits composés, ainsi que l'utilisation de ces derniers à des fins thérapeutiques.
Arora Jalaj
Edwards Louise
Isaac Methvin
Kers Annika
Malmberg Johan
Astrazeneca Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nps Pharmaceuticals Inc.
LandOfFree
Oxadiazoles as modulators of metabotropic glutamate receptor-5 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxadiazoles as modulators of metabotropic glutamate receptor-5, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxadiazoles as modulators of metabotropic glutamate receptor-5 will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1393722