Oxadiazolidinedione compound

Details Oxadiazolidinedione compound Oxadiazolidinedione compound

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2650124

[PROBLEMS] To provide a compound which can be used as a pharmaceutical agent, particularly an insulin secretion enhancer or a prophylactic/therapeutic agent for a disease associated with GPR40 such as diabetes. [MEANS FOR SOLVING PROBLEMS] It is found that an oxadiazolidinedione compound having, at the 2-position of an oxadiazolidinedione ring, a substituent (e.g., a benzyl) bound to a cyclic group through a linker, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity. The oxadiazolidinedione compound shows an excellent insulin secretion enhancing effect and an excellent anti-hyperglycemic effect, and therefore is useful as an insulin secretion enhancer or a prophylactic/therapeutic agent for diabetes.

[PROBLÈMES] Proposer un composé qui peut être utilisé comme agent pharmaceutique, en particulier un activateur de sécrétion d'insuline ou un agent prophylactique/thérapeutique visant une maladie associée à GPR40, comme le diabète. [Moyens de RÉSOUDRE les PROBLÈMES] Un composé d'oxadiazolidinedione ayant, en position 2 d'un cycle oxadiazolidinedione, un substituant (par exemple, un benzyle) lié à un groupe cyclique par l'intermédiaire d'un agent de liaison ou un sel pharmaceutiquement acceptable de celui-ci, a une excellente activité agoniste de GPR40. Le composé d'oxadiazolidinedione présente un excellent effet améliorant la sécrétion de l'insuline et un excellent effet anti-hyperglycémique ; il est, par conséquent, utile comme activateur de la sécrétion d'insuline ou comme agent prophylactique/thérapeutique contre le diabète.

Affiliated with

Also associated with

Rating

Oxadiazolidinedione compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxadiazolidinedione compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxadiazolidinedione compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1581378