Oxadiazoline derivatives

Details Oxadiazoline derivatives Oxadiazoline derivatives

C - Chemistry, Metallurgy

07

D

260/310.7

C07D 271/10 (2006.01)

Patent

CA 1076121

TITLE OXADIAZOLINE DERIVATIVES INVENTORS John Warkentin Kottieth Ramakrishnan Rup C. Jain Frank W. Wandelmaier ABSTRACT OF THE DISCLOSURE Benzylidenehydrazsno-oxadiazoline compounds have been prepared of the formula: Image wherein R1 and R2 are both lower alkyl or form with the heterocyclic ring carbon atom an alicyclic ring; and R3 when present is selected from halogen, lower alkyl and lower alkoxy. The preparation involves condensing a benzaldehyde with carbodihydrazide and further condensing with a ketone (or vice versa) to form the corresponding crossed carbodihydrazone, and oxidizing and cyclizing to form the oxadiazoline derivatives. These derivatives have analgesic and/or anti-inflammatory activity.

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