Oxadiazolopyrimidones, their preparation and application in...

C - Chemistry – Metallurgy – 07 – D

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C07D 498/04 (2006.01) A61K 31/505 (2006.01) C07D 239/50 (2006.01)

Patent

CA 1334847

L'invention concerne de nouvelles oxadiazolo pyrimidinones répondant à la formule (I) ou sa forme isomère de formule (II): Image Image (II) (I) dans lesquelles R3 et R4, identiques ou différents, désignent un atome d'hydrogène ou un radical alkyle, alcényle, cycloalkyle, aryle ou aralkyle, ou R3 et R4 pris ensemble avec l'azote auquel ils son-t reliés forment un héterocycle, R1 désigne un atome d'hydrogène ou un groupement carbamoyle de formule: Image dans laquelle R2 désigne un atome d'hydrogène ou un radical alkyle, alcényle, cycloalkyle, aryle ou aralkyle Les composés selon l'invention sont utiles en cosmétique et dermopharmacie, notamment dans le traitement des maladies du cuir chevelu telles que la pelade, la chute des cheveux, la dermatite desquamante, l'alopécie.

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