Oxadiazolyl-1,4-dihydropyridines and the analogues thereof

Details Oxadiazolyl-1,4-dihydropyridines and the analogues thereof Oxadiazolyl-1,4-dihydropyridines and the analogues thereof

C - Chemistry, Metallurgy

07

D

167/208, 260/266

C07D 413/04 (2006.01) C07D 271/06 (2006.01) C07D 271/10 (2006.01) C07D 285/08 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1326851

Abstract of the Disclosure Novel compounds of formula: Image or a pharmaceutically acceptable acid addition salt thereof wherein A is nitrogen and B is CH; T1 is lower alkylene or lower alkenylene each unsubstituted or substituted by phenylene; or T1 is a single bond; X is Image wherein R6 is hydrogen, lower alkyl, lower cycloalkyl or benzyl; T2 is carbonyl, lower alkylene unsubstituted or substituted by phenyl which in turn is unsubstituted or substituted by lower alkyl or halogen; or T2 is a single bond; R2 is phenyl or phenoxy each unsubstituted or substituted by one or more of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, cyano, lower alkyl, lower alkoxy, methylenedioxy, lower alkylsulfonyl or hydroxy; or R2 is pyridyl, pyrimidinyl, furyl, thienyl, lower cycloalkyl er adamantyl; or when X is -NR4-, R2 and R6 taken together with the nitrogen to which they are attached form pyrrolidinyl, piperidinyl or azacyclooctanyl each unsubstituted or substituted by o-phenylene which in turn is unsubstituted or substituted by phenyl, benzoyl, mono- or dihalophenyl, or mono- or dihalobenzoyl; R13 is phenyl unsubstituted or substituted by one or more of the same or different substituents selected from the group consisting of halogen, nitro, trifluoromethyl, cyano, lower alkyl, lower alkoxy, polyfluoro-lower alkoxy or benzyloxy; R14 is COOR8 wherein R8 is a saturated or unsaturated C1-C10 hydrocarbon radical; or R8 is -T3R9 wherein T3 is lower alkylene and R9 is lower alkoxy, lower cycloalkyl, cyano, polyfluoro-lower alkyl or pyridyl; R1 and R5 are each lower alkyl or lower alkenyl; R7 is hydrogen are useful in the treatment of cardiovascular disorders.

492042

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