Oxalylamino acid derivatives, processes for their...

Details Oxalylamino acid derivatives, processes for their... Oxalylamino acid derivatives, processes for their...

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/40 (2006.01) C07C 233/56 (2006.01) C07C 323/59 (2006.01)

Patent

CA 2042282

HOECHST AKTIENGESELLSCHAFT HOE 90/F 147 Dr. FI/AL Abstract of the Disclosure Title: Oxalylamino acid derivatives, processes for their preparation and their use as medicaments for inhibiting proline hydroxylase The invention relates to oxalylamino acid derivatives of the formula I Image in which R and R' are identical or different and are C1-C8-alkyl or hydrogen, R1 is hydrogen or C1-C4-alkyl, R2 is hydrogen, C1-C8-alkyl, C1-C3-alkoxy, carboxyl, C1-C6-alkoxycarbonyl, aryl, SH, NH2 or halogen, where the alkyl radicals are unsubstituted or substituted by aryl, OH, SH or NH2 or R1 and R2 together are a C2-C4-alkylene chain and the compounds in their predominantly pure D- and L- The compounds are distinguished as excellent inhibitors of prolyl hydroxylase and lysine hydroxylase.

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