C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 497/04 (2006.01) A61K 31/4365 (2006.01) A61M 11/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 27/06 (2006.01) A61P 37/08 (2006.01) C07D 221/00 (2006.01) C07D 327/00 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2379199
This invention provides novel oxathiepino[6,5-<i>b</i>]dihydropyridines. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.
Cette invention concerne de nouveaux oxathiepino[6,5-<i>b</i>]dihydropyridines. Ces composés sont utiles en tant qu'antagonistes du canal calcium pour leur activité cardio-vasculaire, antiasthmatique et anti-bronchorestriction. Ainsi, cette invention ouvre la voie à des compositions pharmaceutiques et à des méthodes convenant pour la prévention et le traitement de troubles divers tels qu'hypersensibilité, manifestations allergiques, asthme, bronchospasme, dysménorrhée, spasme de l'oesophage, glaucome, accouchement prématuré, troubles de l'appareil urinaire, troubles de la motilité gastro-intestinale et pathologies cardio-vasculaires.
Bullington James L.
Dodd John H.
Hall Daniel A.
Henry James R.
Rupert Kenneth C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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