Oxazinone derivative

Details Oxazinone derivative Oxazinone derivative

C - Chemistry, Metallurgy

07

D

C07D 265/22 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2084997

- 69 - A B S T R A C T Disclosed is a novel oxazinone derivative repre- sented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibi- tor: Image . . . [I] where A includes, for example, Image in which W is -O-, -S-, -CH=CH- or -NR9- or means that (CH2)n is directly bonded to (CH2)n, V2 is =CR12- or =N-, and D is 5 to 7-membered carbon ring or hetero ring; X is -O-, -S-, -CO-, or -NR15 or means that A is directly bonded to (CH2)1; Y is -O-, -CH=CH- or -NR16- or means that (CH2)1 is directly bonded to Z; - 70 - z is -CH2- or -CO-; and 1 is an integer of 0 to 4. Further, R and R1 to R16 are hydrogen atom, lower alkyl group, etc.

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