C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/304
C07D 261/08 (2006.01) C07D 263/32 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1287058
RAN 4070/67 Abstract Oxazole and isoxazole derivatives of the formula Image I wherein A signifies C1-6-alkylene, Het signifies a 2-R-oxazol-5-yl, 5-R-oxazol-2-yl, 4-R-oxazol-2-yl, 2-R-oxazol-4-yl, 3-R-isoxazol-5-yl or 5-R-isoxazol- -3-yl group which is optionally substituted on the heterocyclic ring by a C1-6-alkyl group, R signifies phenyl or thienyl monosubstituted or disubstituted by halogen, trifluoromethyl or C1-6-alkylthio, R1 and R2 each signify a C1-6-alkyl group and R3 signi- fies a hydroxy or C1-6 alkoxy group or a group of the formula -NR4R5 in which R4 and R5 each signify a hydrogen atom or a C1-6-alkyl group or R4 and R5 together with the nitrogen atom to which they are attached signify a 5-membered or 6-membered saturated heteromonocyclic ring which may contain an oxygen or sulphur atom or an additional nitrogen atom, and pharmaceutically acceptable salts of the compounds of formula I in which R3 signifies a hydroxy group with bases, have anti-arthritic activity.
519957
Machin Peter J.
Osbond John M.
Self Christopher R.
Smithen Carey E.
Tong Brian P.
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
Roche Holding Ltd.
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