Oxazole derivatives and their uses as tyrosine kinase...

Details Oxazole derivatives and their uses as tyrosine kinase... Oxazole derivatives and their uses as tyrosine kinase...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/422 (2006.01) A61P 35/00 (2006.01) C07D 263/32 (2006.01)

Patent

CA 2404760

A compound represented by formula (1) wherein m is 1 or 2, R1 is a halogen or an optionally halogenated C1-2 alkyl; one of R2 and R3 is a hydrogen atom and the other is a group represented by formula (2) or (3) wherein n is 3 or 4; R4 is a C1-4 alkyl group substituted by 1 or 2 hydroxy groups, or a salt thereof shows tyrosine kinase-inhibiting activity.

L'invention concerne un composé, ou un de ses sels, représenté par la formule (1) dans laquelle m prend la valeur 1 ou 2, R?1¿ représente un halogène ou un groupe alkyle en C¿1-2? éventuellement halogéné, l'un des R?2¿ et R?3¿ représente un atome d'hydrogène et l'autre représente un groupe de formule (2) ou (3) dans laquelle n prend la valeur 3 ou 4, et R?4¿ représente un groupe alkyle en C¿1-4? substitué par 1 ou 2 groupes hydroxy. Ce composé possède une activité inhibitrice de tyrosine kinase.

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