Oxazole derivatives and use thereof

Details Oxazole derivatives and use thereof Oxazole derivatives and use thereof

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/42 (2006.01) C07C 45/00 (2006.01) C07C 49/567 (2006.01) C07C 49/813 (2006.01) C07C 69/007 (2006.01) C07C 233/31 (2006.01) C07C 233/47 (2006.01) C07C 251/42 (2006.01) C07C 311/16 (2006.01) C07C 311/29 (2006.01) C07C 311/32 (2006.01) C07C 311/37 (2006.01) C07C 317/24 (2006.01) C07C 317/32 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2208316

An oxazole derivative represented by general formula (I) or a medicinally acceptable salt thereof, each being excellent in antipyretic, analgesic, antiphlogistic, and particularly selective cyclooxygenase-2 (COX-2) inhibitory effects and promising as an antipyretic, analgesic or antiphlogistic agent reduced in side effects such as gastrointestinal disturbance. In the said formula, one of R and R1 represents methylsulfonylphenyl, aminosulfonylphenyl or alkylaminosulfonylphenyl, and the other of them represents C5-C7 cycloalkyl which may be substituted by lower alkyl, thienyl which may be substituted by lower alkyl or halo, or furanyl which may be substituted by lower alkyl or halo; and R2 represents lower alkyl.

La présente invention concerne un dérivé d'oxazole représenté par la formule générale (I), ou un sel de ce composé qui est acceptable médicalement, chacun étant excellent par ses effets fébrifuges, analgésiques, antiphlogistiques, et particulièrement les effets inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2), qui est prometteuse comme agent fébrifuge, analgésique ou antiphlogistique dont les effets secondaires sont réduits, comme les troubles gastro-intestinaux. Dans la formule (I), R ou R¿1? représente le méthylsulfonylphényle, l'aminosulfonylphényle ou l'alkylaminosulfonylphényle, l'autre représentant un cycloalkyle C¿5?-C¿7? auquel peut se substituer un alkyle inférieur, du thiényle auquel peut se substituer un alkyle ou un halo inférieur, ou un furanyle auquel peut se substituer un alkyle ou un halo inférieur, et R¿2? représente un alkyle inférieur.

Affiliated with

Also associated with

Rating

Oxazole derivatives and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxazole derivatives and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxazole derivatives and use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1840640