Oxazole derivatives as inhibitors of cyclooxygenase

Details Oxazole derivatives as inhibitors of cyclooxygenase Oxazole derivatives as inhibitors of cyclooxygenase

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01) A61K 31/42 (2006.01) C07D 263/34 (2006.01) C07D 263/38 (2006.01) C07D 263/46 (2006.01) C07D 263/48 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2513295

A compound of the formula (I): wherein R1 is cycloalkyl, etc; R2 is (lower)alkoxy, etc; R3 is (lower)alkylene, etc; R4 is (lower)alkylene, etc; R5 is hydroxy, etc; X is "0", "S", "SO", or "S02"; Y is "CH" or "N"; n is 0 or 1; or pharmaceutically acceptable salts thereof, which are useful as a medicament.

L'invention concerne un composé représenté par la formule générale (I) dans laquelle R?1¿ désigne un cycloalkyle, etc. ; R?2¿ désigne un alcoxy (inférieur), etc. ; R?3¿ désigne un alkylène (inférieur), etc. ; R?4¿ désigne un alkylène (inférieur), etc. ; R?5¿ désigne un hydroxy, etc. ; X désigne <= 0 >=, <= S >=, <= SO >=, ou <= SO¿2? >= ; Y désigne <= CH>= ou <= N >= ; n vaut 0 ou 1 ; ou un de ses sels de qualité pharmaceutique, pouvant être utilisés comme un médicament.

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