Oxazole derivatives as positive allosteric modulators of...

Details Oxazole derivatives as positive allosteric modulators of... Oxazole derivatives as positive allosteric modulators of...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2668679

The present invention provides new compounds of formula (I), wherein P3A, W, B, Q, Rl and R2 are defined as in formula (I); invention compounds are positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example: cognitive decline, both positive and negative symptoms in schizophrenia as well as other disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved.

La présente invention concerne de nouveaux composés répondant à la formule (I), P3A, W, B, Q, Rl et R2 étant tels qu'ils sont définis dans la formule (I). Les composés de l'invention sont des modulateurs allostériques positifs des récepteurs métabotropiques, de sous-type 5 (<= mGluR5 >=), qui se révèlent utiles pour le traitement ou la prévention de troubles du système nerveux central tels que, par exemple, un déclin cognitif, les symptômes tant positifs que négatifs de la schizophrénie, ainsi que d'autres troubles qui impliquent le sous-type mGluR5 du récepteur métabotropique du glutamate.

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