C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2732526
The present invention is directed to certain oxazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
La présente invention concerne certains dérivés d'oxazole qui sont utiles comme inhibiteurs d'amide hydrolase d'acide gras (FAAH). L'invention concerne également des formulations pharmaceutiques comprenant ces composés comme ingrédients actifs et l'utilisation des composés et de leurs formulations dans le traitement de certaines affections, notamment ostéoarthrite, polyarthrite rhumatoïde, neuropathie diabétique, algie post-zona, douleur squeletto-musculaire, et fibromyalgie, ainsi que douleur aiguë, migraine, trouble du sommeil, maladie d'Alzheimer et maladie de Parkinson.
Chioda Marc D.
Chobanian Harry
Devita Robert J.
Guo Yan
Lin Linus S.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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