C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/14 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61P 27/06 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 277/14 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2495917
This invention relates to compounds of formula (I) which are potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient.
L'invention porte sur de puissants antagonistes sélectifs du sous-type EP¿4 ?des récepteurs E2 de la prostaglandine, sur leur utilisation, ou celle de préparations les contenant, pour le traitement du glaucome et d'autres états liés à l'élévation de la tension intraoculaire de patients. L'invention porte également sur l'utilisation des composés de l'invention pour médier les processus de modelage et de remodelage osseux des ostéoblastes et des ostéoclastes.
Billot Xavier
Colucci John
Han Yongxin
Wilson Marie-Claire
Young Robert
Merck Frosst Canada & Co./merck Frosst Canada & Cie
Merck Frosst Canada Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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