C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61P 31/04 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 417/14 (2006.01) C07F 7/18 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2507468
A compound of the formula (I), or a pharmaceutically-acceptable salt, or in- vivo hydrolysable ester thereof: formula (I) wherein in (I) C is for example formula (D), formula (E), formula (H) wherein A and B are independently selected from (i) formula (J) and (ii) formula (K) m is 1 or 2; R2b and R6b, R2a and R6a, R3a and R5a, are for example selected from H, F, OMe and Me; R2b' and R6b', R2a' and R6a', R3a', R5a' are for example selected from H, OMe and Me; R1a is for example optionally substituted (1-10C)alkyl; R1b is for example selected from -NR5C(=W)R4, formula (a) , or formula (b) wherein HET-1 is for example isoxazolyl and HET-2 is for example triazolyl or tetrazolyl. Methods for making compounds of the formula (I), compositions containing them and their use as antibacterial agents are also described.
L'invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable ou un ester hydrolysable in vivo dudit composé. Dans cette formule, C est représenté, par exemple, par la formule (D), la formule (E) ou la formule (H), dans lesquelles A et B sont indépendamment choisis parmi la formule (i) et la formule (ii), m vaut 1 ou 2, R¿2?b et R¿6?b, R¿2?a et R¿6?a et R¿3?a et R¿5?a sont, par exemple, choisis parmi H, F, OMe et Me, R¿2?b' et R¿6?b', R¿2?a' et R¿6?a', R¿3?a' et R¿5?a' sont, par exemple, choisis parmi H, OMe et Me, et R¿1?b est, par exemple, chois parmi NR¿5?C(=W)R¿4?. Dans la formule (a) ou la formule (b), HET-1 est, par exemple, isoxazolyle, et HET-2 est, par exemple, triazolyle ou tétrazolyle. L'invention concerne également des procédés de préparation des composés de formule (I), des compositions les contenant ainsi que leur utilisation comme agents antibactériens.
Carcanague Daniel Robert
Gravestock Michael Barry
Hales Neil James
Hauck Sheila Irene
Weber Thomas Peter
Astrazeneca Ab
Fetherstonhaugh & Co.
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