C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/20 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07F 9/653 (2006.01) C07B 61/00 (2006.01)
Patent
CA 2318969
Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
L'invention se rapporte à des oxazolidinones et à des procédés de synthèse de ces composés. Elle se rapporte également à des banques combinatoires comportant des oxazolidinones ainsi qu'à des procédés de préparation de telles banques. Elle se rapporte aussi à des procédés de fabrication d'oxazolidinones biologiquement actives ainsi qu'à des compositions pharmaceutiquement acceptables contenant ces oxazolidinones. Les procédés de préparation de ces banques de composés consistent à fixer ces oxazolidinones à un support solide. Les procédés de préparation de ces composés consistent, dans une réalisation de l'invention, à faire réagir un iminophosphorane avec un support polymère contenant un carbonyle.
Gordeev Mikhail F.
Gordon Eric
Luehr Gary W.
Ni Zhi-Jie
Patel Dinesh V.
Macrae & Co.
Pharmacia & Upjohn Company
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