Oxazolidinone derivatives, processes for their preparation,...

Details Oxazolidinone derivatives, processes for their preparation,... Oxazolidinone derivatives, processes for their preparation,...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2477379

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in- vivo-hydrolysable ester thereof, wherein -N-HET is, for example, formula (Ic) or (If) wherein R1 is, for example, halogen or a (1-4C)alkyl group which is substituted by one substituent selected from, for example, hydroxy, (1- 4C)alkoxy, amino, cyano or azido; Q is selected from, for example, Q1, formula Q1 wherein R2 and R3 are independently hydrogen or fluoro;T is selected from a range of groups, for example, formula (TC12b) wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

La présente invention a trait à des composés chimiques de formule (I), ou un sel pharmaceutiquement acceptable, ou un ester hydrolysable in vivo de ceux-ci, formule dans laquelle : N-HET est, par exemple, de formule (Ic) ou (If), dans lesquelles R1 est, par exemple, halogène ou un groupe alkyle en C¿1?-C¿4? qui est substitué par un substituant choisi parmi, par exemple, un groupe hydroxy, alcoxy en C¿1?-C¿4?, amino, cyano ou azido ; Q est choisi parmi, par exemple, la formule Q1 dans laquelle R?2¿ et R?3¿ sont indépendamment hydrogène ou fluoro ; T est choisi d'une gamme de groupes, par exemple, de formule (TC12b), dans laquelle m est 0, 1 ou 2. Lesdits composés sont utiles en tant qu'agents antibactériens. L'invention a trait également à des procédés pour la fabrication desdits composés et des compositions pharmaceutiques les contenant.

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