Oxazolidinones having a sulfoximine functionality and their...

Details Oxazolidinones having a sulfoximine functionality and their... Oxazolidinones having a sulfoximine functionality and their...

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2389482

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: A is a structure i, ii, iii, or iv; B is (a), (b), (c) W is NHC(=X)R1, or -Y-het; provided that when A is a structure iv, W is not -Y-het; Z is S(=O)(=N-R5); and R2 and R3 are independently H, F, CI, methyl or ethyl; which have potent activities against Gram-positive and Gram- negative bacteria.

La présente invention concerne un composé de formule (I) ou un sel pharmaceutiquement acceptable dudit composé. Dans cette formule, A est une structure i, ii, iii ou iv, B est (a), (b) ou (c), Z représentant S(=O)(=N-R¿5?), W est NHC(=X)R¿1? ou Y-het, à condition que W ne soit pas Y-het lorsque A est une structure iv, et R¿2? et R¿3? sont indépendamment H, F, Cl, méthyle ou éthyle. Lesdits composés combattent efficacement les bactéries Gram-positives et Gram-négatives.

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