Oxazolidone derivatives as pr modulators

Details Oxazolidone derivatives as pr modulators Oxazolidone derivatives as pr modulators

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/433 (2006.01) A61P 15/00 (2006.01) C07D 263/48 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2659208

Compounds of the structure (I) are described, wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

La présente invention concerne des composés représentés par la structure (I), R1, R2, R5, R6, V, X, Y, Z et Q étant définis dans ce document, ou un sel, un tautomère, un métabolite ou un promédicament pharmaceutiquement acceptable de ces composés. Lesdits composés se révèlent utiles pour traiter une variété de pathologies associées aux hormones incluant la contraception, pour traiter ou prévenir des léiomyomes, une endométriose, une ménométrorragie, un léiomyome utérin, un syndrome des ovaires polykystiques, ou des carcinomes hormono-dépendants, pour offrir une thérapie de substitution hormonale, pour stimuler la prise alimentaire ou pour synchroniser l'AEstrus.

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