Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines...

Details Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines... Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines...

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/44 (2006.01) C07D 221/00 (2006.01) C07D 263/00 (2006.01) C07D 277/00 (2006.01) C07D 293/00 (2006.01) C07D 513/04 (2006.01) C07D 513/14 (2006.01) C07D 517/04 (2006.01)

Patent

CA 2338504

Thiazolo-, oxazolo- and selenazolo[4,5-c]quinoline-4-amines (see formula I) and analogs thereof are described including methods of manufacture and the use of novel intermediates. The compounds are immunomodulators and induce cytokine biosynthesis, including interferon and/or tumor biosynthesis, necrosis factor, and inhibit the T-helper-type 2 immune response. The compounds are further useful in the treatment of viral and neoplastic diseases.

L'invention concerne des oxazolo-, thiazolo- et sélénazolo [4,5-c]-quinoline-4-amines et leurs analogues, y compris des procédés de fabrication et d'utilisation de nouveaux intermédiaires. Les composés sont des immunomodulateurs et induisent la biosynthèse de cytokines, y compris la biosynthèse d'interférons et/ou tumorale, le facteur de nécrose et inhibent la réponse immunitaire de Thl type 2. Les composés sont également utiles pour traiter des maladies virales et néoplasiques.

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